Salivary Hormone Panels:

The hypothalamic-pituitary-adrenal (HPA) axis is crucial component of the Neurocrine network, and it regulates stress management, energy and mood. Stress activates the HPA, and its primary function is to release glucocorticoids such as cortisol. Cortisol is one of the most frequently employed glucocorticoid biomarkers because the cortisol abnormal levels are due to acute and chronic stress, linked to many cognitive and behavioral functioning. PacifiqueBio offers hormone testing non-invasive, at-home collection kits to evaluate the bio-available reproductive and cortisol levels in tissue and enables to optimize and monitor the personalized treatment for the following conditions, such as fatigue, weight change, menstrual irregularity, libido change, insomnia, muscle mass change, certain cardiovascular disease, mood swings, Cushing syndrome, depression and anxiety, and many more.

 

  • Adrenal Stress Panel: Cortisol x 4 times to address diurnal rhythm and DHEAS x 1 time DHEAS:Cortisol Ratio
  • Diurnal Cortisol Panel: Cortisol x 4 times
  • Cortisol Awakening Response: Cortisol x 3 times
  • Baseline Hormone Evaluation: Testosterone, Progesterone, Estradiol, DHEAS, Progesterone:Estradiol Ratio
  • Hormone Circadian Profile: Testosterone, Progesterone, Estradiol, DHEAS, Progesterone:Estradiol Ratio and Cortisol x 4 times
  • Female Hormone Comprehensive Profile: Progesterone and Estradiol x 7 times starting on day 2, 10, 12, 14, 16, 18 and 24 of the menstruation, Testosterone, DHEAS x 1 time, Cortisol x 4 times.

Amino Acids Panel:

Amino acids are protein and peptide building blocks that play a fundamental role in many metabolic pathways, cellular signaling, gene expression, and acting as substrates for energy production. Some amino acids that are obtained from dietary sources are known as essential amino acids, whereas some amino acids that our bodies can produce from essential amino acids or other sources are called non-essentials. Although, only 20 amino acids are commonly used in protein synthesis, but more than 100 amino acids occur naturally, and at least 80% of these has important biological roles.

 

Comprehensive analysis of physiologic amino acids in bodily fluids is typically performed in the following clinical settings:

  • Evaluation of symptomatic patients in whom a diagnosis is not known.
  • Evaluation of previously diagnosed patients to monitor treatment efficacy.
  • Evaluation of asymptomatic or pre-symptomatic relatives of known patients.
  • Follow-up testing for an abnormal newborn screen.
  • Assessment of dietary protein adequacy or renal function in general patient populations.

Specific abnormalities in amino acid concentrations are reported in the context of various diseases, including liver failure, renal failure, cancer, diabetes, fatty liver, muscle dysfunction, Alzheimer’s disease, depression, anxiety, sleep related issues, protein malnutrition and weight related issues.

  • 53 target molecules (essential and non-essential amino acids, and their metabolites)
  • Affordable
  • Convenient and pain-free from home test kits
  • Short turnaround time
  • Rigorous Quality Control

Biogenic Amines Panel:

Biogenic amines panel will include catecholamines – dopamine, norepinephrine and epinephrine, and their catechol-O-methyl transferase (COMT) metabolites – 3-methoxytyramine, normetanephrine, metanephrine, respectively and serotonin as monoamine neurotransmitter. These hormones and neurotransmitters play a key role in modulating psychomotor function, cardiovascular, respiratory, and gastrointestinal control, sleep mechanism, hormone secretion, body temperature and pain. Abnormal urinary level of biogenic monoamines is associated with cardiovascular diseases and neuropathologies related to neuropsychiatric and neurodegenerative diseases.

 

  • Catecholamine neurotransmitters (dopamine, norepinephrine, epinephrine), their metabolites (3-methoxytyramine, metanephrine, normetanephrine), and serotonin.
  • Affordable
  • Convenient and pain-free
  • Short turnaround time
  • Rigorous Quality Control

Methylation Markers Panel:

Methylation is a chemical reaction where a chemical entity called methyl group (-CH3) gets added to nucleic acids (DNA), proteins, phospholipids, and monoamine neurotransmitters, thereby altering their structure and function. This transformation is catalyzed to a large extent by enzymes S-adenosylmethionine (SAMe) dependent methyltransferases which play a significant role in fundamental biological processes such as:

 

  • Signaling inside the cells and production of membrane components
  • Fat metabolism
  • Hormonal regulation and detoxification
  • Immune function
  • Neurotransmitters production and metabolism
  • Protein expression machinery
  • Synthesis of DNA/RNA

PacifiqueBio’s Methylation Markers panel is an innovative tool for the assessment of the disturbance in the transmethylation and trans-sulfuration pathways.

  • Methionine, S-Adenosylhomocysteine, homocystine, cystine, serine, glycine, cystathionine, cysteine sulfate, taurine, sarcosine.
  • Affordable
  • Convenient and pain-free
  • Short turnaround time
  • Rigorous Quality Control

Neurotransmitters Panel:

Neurotransmitters are the chemical messengers released from neurons and are essential for relaying, amplifying, and modulating signals to other cells throughout the body. Neurotransmitters are key players in neurological, endocrinological and immune system functioning. Therefore, the measurement of levels of neurotransmitters has a significant potential as a clinical tool to analyze nervous system dysfunction which are known to underlie many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis (ALS), mood disorders, adrenal dysfunction, OCD, ADD/ADHD, and sleep disorders. Urinary neurotransmitter testing, due to its stability, sensitivity, and non-invasiveness, is the desired method to evaluate the adequacy and efficacy of the treatment.

 

  • Major monoamine and amino acid neurotransmitters (Dopamine, norepinephrine, epinephrine, serotonin, GABA, glutamic acid, 5-HTP and histamine).
  • Affordable
  • Convenient and pain-free
  • Short turnaround time
  • Rigorous Quality Control